Response to SARS-CoV-2 vaccination in systemic autoimmune rheumatic disease depends on immunosuppressive regimen: a matched, prospective cohort study

P Mandl, S Tobudic, H Haslacher… - Annals of the …, 2022 - ard.bmj.com
P Mandl, S Tobudic, H Haslacher, T Karonitsch, D Mrak, T Nothnagl, T Perkmann, H Radner
Annals of the rheumatic diseases, 2022ard.bmj.com
Objective To assess the humoral response to messenger RNA (mRNA) vaccine of patients
with systemic autoimmune rheumatic disease (SARD) and the effect of immunosuppressive
medication in a matched cohort study. Methods Patients with SARD were enrolled and
matched 1: 1 for sex and age with healthy control (HC) subjects. Differences in humoral
response to two doses of an mRNA vaccine in terms of seroconversion rate (SCR) and
SARS-CoV-2 antibody level between the two groups and the impact of treatment within …
Objective
To assess the humoral response to messenger RNA (mRNA) vaccine of patients with systemic autoimmune rheumatic disease (SARD) and the effect of immunosuppressive medication in a matched cohort study.
Methods
Patients with SARD were enrolled and matched 1:1 for sex and age with healthy control (HC) subjects. Differences in humoral response to two doses of an mRNA vaccine in terms of seroconversion rate (SCR) and SARS-CoV-2 antibody level between the two groups and the impact of treatment within patients with SARD were assessed.
Results
We enrolled 82 patients with SARD and 82 matched HC. SCR after the first dose was lower among the patient group than that of HC (65% compared with 100% in HC, p<0.0001) but levelled up after the second dose (94% vs 100%). After the second dose, SCR was lower for patients on combination disease-modifying antirheumatic drug (DMARD) therapy compared with all other groups (81% compared with 95% for monotherapy, p=0.01; 100% for both no DMARD therapy and HC, both p<0.0001). In addition, antibody levels after both doses were lower in patients compared with HC. We found that vaccination response was determined primarily by the number of DMARDs and/or glucocorticoids received, with patients receiving combination therapy (dual and triple therapy) showing the poorest response.
Conclusions
Patients with SARD showed a good response after the second vaccination with an mRNA vaccine. However, the choice of immunosuppressive medication has a marked effect on both SCR and overall antibody level, and the number of different immunomodulatory therapies determines vaccination response.
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