A modified method for heterotopic mouse heart transplantion

C Wang, Z Wang, R Allen, GA Bishop… - JoVE (Journal of …, 2014 - jove.com
Mice are often used as heart transplant donors and recipients in studies of transplant
immunology due to the wide range of transgenic mice and reagents available. A difficulty is
presented due to the small size of the animal and the considerable technical challenges of
the microsurgery involved in heart transplantation. In particular, a high rate of technical
failure early after transplantation may result from recipient death and post-operative
complications such as hind limb paralysis or a non-beating heart. Here, the complete …