[HTML][HTML] Tracking of TCR-transgenic T cells reveals that multiple mechanisms maintain cardiac transplant tolerance in mice
ML Miller, MD Daniels, T Wang, Y Wang, J Xu… - American Journal of …, 2016 - Elsevier
Solid organ transplantation tolerance can be achieved following select transient
immunosuppressive regimens that result in long-lasting restraint of alloimmunity without
affecting responses to other antigens. Transplantation tolerance has been observed in
animal models following costimulation or coreceptor blockade therapies, and in a subset of
patients through induction protocols that include donor bone marrow transplantation, or
following withdrawal of immunosuppression. Previous data from our lab and others have …
immunosuppressive regimens that result in long-lasting restraint of alloimmunity without
affecting responses to other antigens. Transplantation tolerance has been observed in
animal models following costimulation or coreceptor blockade therapies, and in a subset of
patients through induction protocols that include donor bone marrow transplantation, or
following withdrawal of immunosuppression. Previous data from our lab and others have …