Intranasal administration of CNS therapeutics to awake mice
LR Hanson, JM Fine, AL Svitak, KA Faltesek - JoVE (Journal of Visualized …, 2013 - jove.com
Intranasal administration is a method of delivering therapeutic agents to the central nervous
system (CNS). It is non-invasive and allows large molecules that do not cross the blood-
brain barrier access to the CNS. Drugs are directly targeted to the CNS with intranasal
delivery, reducing systemic exposure and thus unwanted systemic side effects1. Delivery
from the nose to the CNS occurs within minutes along both the olfactory and trigeminal
neural pathways via an extracellular route and does not require drug to bind to any receptor …
system (CNS). It is non-invasive and allows large molecules that do not cross the blood-
brain barrier access to the CNS. Drugs are directly targeted to the CNS with intranasal
delivery, reducing systemic exposure and thus unwanted systemic side effects1. Delivery
from the nose to the CNS occurs within minutes along both the olfactory and trigeminal
neural pathways via an extracellular route and does not require drug to bind to any receptor …