Brain region specific actions of regulator of G protein signaling 4 oppose morphine reward and dependence but promote analgesia
MH Han, W Renthal, RH Ring, Z Rahman… - Biological …, 2010 - Elsevier
BACKGROUND: Regulator of G protein signaling 4 (RGS4) is one of the smaller members of
the RGS family of proteins, which are known to control signaling amplitude and duration via
interactions with G protein α subunits or other signaling molecules. Earlier evidence
suggests dynamic regulation of RGS4 levels in neuronal networks mediating actions of
opiates and other drugs of abuse, but the consequences of RGS4 actions in vivo are largely
unknown. METHODS: In this study, we use constitutive and nucleus accumbens-inducible …
the RGS family of proteins, which are known to control signaling amplitude and duration via
interactions with G protein α subunits or other signaling molecules. Earlier evidence
suggests dynamic regulation of RGS4 levels in neuronal networks mediating actions of
opiates and other drugs of abuse, but the consequences of RGS4 actions in vivo are largely
unknown. METHODS: In this study, we use constitutive and nucleus accumbens-inducible …