Adenosine is a modulator of brain function uniquely positioned to integrate excitatory and
inhibitory neurotransmission. The past few years brought a wealth of new data fostering our
understanding of how the adenosine system is involved in the pathogenesis of neurological
diseases. Thus, dysregulation of the adenosine system is implicated in epileptogenesis and
cell therapies have been developed to locally augment adenosine in an approach to prevent
seizures. While activation of inhibitory adenosine A1 receptors is beneficial in epilepsy …