[HTML][HTML] Involvement of napsin A in the C-and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung
F Brasch, M Ochs, T Kähne, S Guttentag… - Journal of Biological …, 2003 - ASBMB
Surfactant protein B (SP-B) is a critical component of pulmonary surfactant, and a deficiency
of active SP-B results in fatal respiratory failure. SP-B is synthesized by type-II pneumocytes
as a 42-kDa propeptide (proSP-B), which is posttranslationally processed to an 8-kDa
surface-active protein. Napsin A is an aspartic protease expressed in type-II pneumocytes.
To characterize the role of napsin A in the processing of proSP-B, we colocalized napsin A
and precursors of SP-B as well as SP-B in the Golgi complex, multivesicular, composite, and …
of active SP-B results in fatal respiratory failure. SP-B is synthesized by type-II pneumocytes
as a 42-kDa propeptide (proSP-B), which is posttranslationally processed to an 8-kDa
surface-active protein. Napsin A is an aspartic protease expressed in type-II pneumocytes.
To characterize the role of napsin A in the processing of proSP-B, we colocalized napsin A
and precursors of SP-B as well as SP-B in the Golgi complex, multivesicular, composite, and …