Chronic inflammation of the placenta: definition, classification, pathogenesis, and clinical significance

CJ Kim, R Romero, P Chaemsaithong… - American journal of …, 2015 - Elsevier
Chronic inflammatory lesions of the placenta are characterized by the infiltration of the organ
by lymphocytes, plasma cells, and/or macrophages and may result from infections (viral,
bacterial, parasitic) or be of immune origin (maternal anti-fetal rejection). The 3 major lesions
are villitis (when the inflammatory process affects the villous tree), chronic chorioamnionitis
(which affects the chorioamniotic membranes), and chronic deciduitis (which involves the
decidua basalis). Maternal cellular infiltration is a common feature of the lesions. Villitis of …