Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor
A Carazo, L Hyrsova, J Dusek, H Chodounska… - Toxicology Letters, 2017 - Elsevier
Abstract The Pregnane X (PXR), Vitamin D (VDR) and Farnesoid X (FXR) nuclear receptors
have been shown to be receptors of bile acids controlling their detoxification or synthesis.
Chenodeoxycholic (CDCA) and lithocholic (LCA) acids are ligands of FXR and VDR,
respectively, whereas 3-keto and acetylated derivates of LCA have been described as
ligands for all three receptors. In this study, we hypothesized that oxidation or acetylation at
position 3, 7 and 12 of bile acids DCA (deoxycholic acid), LCA, CA (cholic acid), and CDCA …
have been shown to be receptors of bile acids controlling their detoxification or synthesis.
Chenodeoxycholic (CDCA) and lithocholic (LCA) acids are ligands of FXR and VDR,
respectively, whereas 3-keto and acetylated derivates of LCA have been described as
ligands for all three receptors. In this study, we hypothesized that oxidation or acetylation at
position 3, 7 and 12 of bile acids DCA (deoxycholic acid), LCA, CA (cholic acid), and CDCA …