COVID-19 and microvascular disease: pathophysiology of SARS-CoV-2 infection with focus on the renin-angiotensin system

DA Kasal, A De Lorenzo, E Tibirica - Heart, Lung and Circulation, 2020 - Elsevier
The recently described severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
infected millions of people, with thousands of fatalities. It has prompted global efforts in
research, with focus on the pathophysiology of coronavirus disease-19 (COVID-19), and a
rapid surge of publications. COVID-19 has been associated with a myriad of clinical
manifestations, including the lungs, heart, kidneys, central nervous system, gastrointestinal
system, skin, and blood coagulation abnormalities. The endothelium plays a key role in …