[HTML][HTML] Disruption of rhodopsin dimerization with synthetic peptides targeting an interaction interface
B Jastrzebska, Y Chen, T Orban, H Jin… - Journal of Biological …, 2015 - ASBMB
Although homo-and heterodimerizations of G protein-coupled receptors (GPCRs) are well
documented, GPCR monomers are able to assemble in different ways, thus causing
variations in the interactive interface between receptor monomers among different GPCRs.
Moreover, the functional consequences of this phenomenon, which remain to be clarified,
could be specific for different GPCRs. Synthetic peptides derived from transmembrane (TM)
domains can interact with a full-length GPCR, blocking dimer formation and affecting its …
documented, GPCR monomers are able to assemble in different ways, thus causing
variations in the interactive interface between receptor monomers among different GPCRs.
Moreover, the functional consequences of this phenomenon, which remain to be clarified,
could be specific for different GPCRs. Synthetic peptides derived from transmembrane (TM)
domains can interact with a full-length GPCR, blocking dimer formation and affecting its …