The P23H opsin mutation is the most common cause of autosomal dominant retinitis
pigmentosa. Even though the pathobiology of the resulting retinal degeneration has been
characterized in several animal models, its complex molecular mechanism is not well
understood. Here, we expressed P23H bovine rod opsin in the nervous system of
Caenorhabditis elegans. Expression was low due to enhanced protein degradation. The
mutant opsin was glycosylated, but the polysaccharide size differed from that of the normal …