[HTML][HTML] Tumor microenvironment macrophage inhibitory factor directs the accumulation of interleukin-17-producing tumor-infiltrating lymphocytes and predicts …

J Li, HY Mo, G Xiong, L Zhang, J He, ZF Huang… - Journal of Biological …, 2012 - ASBMB
The accumulation of an intratumoral CD4+ interleukin-17-producing subset (Th17) of tumor-
infiltrating lymphocytes (TILs) is a general characteristic in many cancers. The relationship
between the percentage of Th17 cells and clinical prognosis differs among cancers. The
mechanism responsible for the increasing percentage of such cells in NPC is still unknown,
as is their biological function. Here, our data showed an increase of Th17 cells in tumor
tissues relative to their numbers in normal nasopharynx tissues or in the matched peripheral …