Metabolic regulation of insulin secretion
K Keane, P Newsholme - Vitamins & Hormones, 2014 - Elsevier
Regulation of metabolic fuel homeostasis is a critical function of β-cells, which are located in
the islets of Langerhans of the animal pancreas. Impairment of this β-cell function is a
hallmark of pancreatic β-cell failure and may lead to development of type 2 diabetes
mellitus. β-Cells are essentially “fuel sensors” that monitor and react to elevated nutrient
load by releasing insulin. This response involves metabolic activation and generation of
metabolic coupling factors (MCFs) that relay the nutrient signal throughout the cell and …
the islets of Langerhans of the animal pancreas. Impairment of this β-cell function is a
hallmark of pancreatic β-cell failure and may lead to development of type 2 diabetes
mellitus. β-Cells are essentially “fuel sensors” that monitor and react to elevated nutrient
load by releasing insulin. This response involves metabolic activation and generation of
metabolic coupling factors (MCFs) that relay the nutrient signal throughout the cell and …