[HTML][HTML] Ornithine aminotransferase, an important glutamate-metabolizing enzyme at the crossroads of multiple metabolic pathways
Ornithine δ-aminotransferase (OAT, EC 2.6. 1.13) catalyzes the transfer of the δ-amino
group from ornithine (Orn) to α-ketoglutarate (aKG), yielding glutamate-5-semialdehyde and
glutamate (Glu), and vice versa. In mammals, OAT is a mitochondrial enzyme, mainly
located in the liver, intestine, brain, and kidney. In general, OAT serves to form glutamate
from ornithine, with the notable exception of the intestine, where citrulline (Cit) or arginine
(Arg) are end products. Its main function is to control the production of signaling molecules …
group from ornithine (Orn) to α-ketoglutarate (aKG), yielding glutamate-5-semialdehyde and
glutamate (Glu), and vice versa. In mammals, OAT is a mitochondrial enzyme, mainly
located in the liver, intestine, brain, and kidney. In general, OAT serves to form glutamate
from ornithine, with the notable exception of the intestine, where citrulline (Cit) or arginine
(Arg) are end products. Its main function is to control the production of signaling molecules …
Ornithine δ-aminotransferase (OAT, E.C. 2.6.1.13) catalyzes the transfer of the δ-amino group from ornithine (Orn) to α-ketoglutarate (aKG), yielding glutamate-5-semialdehyde and glutamate (Glu), and vice versa. In mammals, OAT is a mitochondrial enzyme, mainly located in the liver, intestine, brain, and kidney. In general, OAT serves to form glutamate from ornithine, with the notable exception of the intestine, where citrulline (Cit) or arginine (Arg) are end products. Its main function is to control the production of signaling molecules and mediators, such as Glu itself, Cit, GABA, and aliphatic polyamines. It is also involved in proline (Pro) synthesis. Deficiency in OAT causes gyrate atrophy, a rare but serious inherited disease, a further measure of the importance of this enzyme.
MDPI