[HTML][HTML] Characterization of a functional ZBP-89 binding site that mediates Gata1 gene expression during hematopoietic development
K Ohneda, S Ohmori, Y Ishijima, M Nakano… - Journal of biological …, 2009 - ASBMB
GATA-1 is a lineage-restricted transcription factor that plays essential roles in hematopoietic
development. The Gata1 gene hematopoietic enhancer allowed Gata1 reporter expression
in erythroid cells and megakaryocytes of transgenic mice. The Gata1 hematopoietic
enhancer activity is strictly dependent on a GATA site located in the 5′ region of the
enhancer. However, the importance of the GC-rich region adjacent to the 3′-end of this
GATA site has been also suggested. In this study, we show that this GC-rich region contains …
development. The Gata1 gene hematopoietic enhancer allowed Gata1 reporter expression
in erythroid cells and megakaryocytes of transgenic mice. The Gata1 hematopoietic
enhancer activity is strictly dependent on a GATA site located in the 5′ region of the
enhancer. However, the importance of the GC-rich region adjacent to the 3′-end of this
GATA site has been also suggested. In this study, we show that this GC-rich region contains …