[HTML][HTML] Fidelity consequences of the impaired interaction between DNA polymerase epsilon and the GINS complex

M Garbacz, H Araki, K Flis, A Bebenek, AE Zawada… - DNA repair, 2015 - Elsevier
DNA polymerase epsilon interacts with the CMG (Cdc45-MCM-GINS) complex by Dpb2p,
the non-catalytic subunit of DNA polymerase epsilon. It is postulated that CMG is
responsible for targeting of Pol ɛ to the leading strand. We isolated a mutator dpb2-100
allele which encodes the mutant form of Dpb2p. We showed previously that Dpb2-100p has
impaired interactions with Pol2p, the catalytic subunit of Pol ɛ. Here, we present that Dpb2-
100p has strongly impaired interaction with the Psf1 and Psf3 subunits of the GINS complex …