The IL-2 cytokine family in cancer immunotherapy

GC Sim, L Radvanyi - Cytokine & growth factor reviews, 2014 - Elsevier
The use of cytokines from the IL-2 family (also called the common γ chain cytokine family)
such as interleukin (IL)-2, IL-7, IL-15, and IL-21 to activate the immune system of cancer
patients is one of the most important areas of current cancer immunotherapy research. The
infusion of IL-2 at low or high doses for multiple cycles in patients with metastatic melanoma
and renal cell carcinoma was the first successful immunotherapy for cancer proving that the
immune system could completely eradicate tumor cells under certain conditions. The initial …