[HTML][HTML] Transcriptional activation of the SALL1 by the human SIX1 homeodomain during kidney development
SALL1 is a member of the SAL gene family that encodes a group of putative developmental
transcription factors. SALL1 plays a critical role during kidney development as mutations of
the human SALL1 gene cause Townes-Brocks syndrome, which is associated with kidney
malformation. Deletion of the mouse Sall1 gene results in renal agenesis or severe
dysgenesis. To date, little is known about the molecular mechanisms controlling the
regulation of SALL1 expression. This report describes the cloning and characterization of …
transcription factors. SALL1 plays a critical role during kidney development as mutations of
the human SALL1 gene cause Townes-Brocks syndrome, which is associated with kidney
malformation. Deletion of the mouse Sall1 gene results in renal agenesis or severe
dysgenesis. To date, little is known about the molecular mechanisms controlling the
regulation of SALL1 expression. This report describes the cloning and characterization of …