Impaired translation of CCAAT/enhancer binding protein α mRNA in bronchial smooth muscle cells of asthmatic patients
P Borger, N Miglino, M Baraket, JL Black… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: Bronchial smooth muscle (BSM) cells of asthmatic patients have an
impaired expression of CCAAT/enhancer binding protein (C/EBP) α, which is associated
with increased proliferation. OBJECTIVE: We sought to assess the translational regulation of
CEBPA mRNA in cultured BSM cells of healthy control subjects (n= 11) and asthmatic
patients (n= 12). METHODS: Translation efficiency was studied by using a translation control
reporter system driven by the control elements present in the CEBPA mRNA. Translation …
impaired expression of CCAAT/enhancer binding protein (C/EBP) α, which is associated
with increased proliferation. OBJECTIVE: We sought to assess the translational regulation of
CEBPA mRNA in cultured BSM cells of healthy control subjects (n= 11) and asthmatic
patients (n= 12). METHODS: Translation efficiency was studied by using a translation control
reporter system driven by the control elements present in the CEBPA mRNA. Translation …