Intracellular signaling pathways activated by kisspeptins through GPR54: do multiple signals underlie function diversity?
JP Castaño, AJ Martínez-Fuentes, E Gutiérrez-Pascual… - Peptides, 2009 - Elsevier
Kisspeptins, a family of peptide products derived from the KiSS-1 gene, activate their
cognate receptor GPR54 in various target tissues to exert disparate functions, including
inhibition of tumor metastasis and control of reproductive function. In contrast to the plethora
of studies that have analyzed in recent years the regulatory functions of the KiSS-1/GPR54
system, only a limited number of reports have been primarily focused on delineating the
intracellular signaling pathways involved. Nevertheless, there is solid evidence indicating …
cognate receptor GPR54 in various target tissues to exert disparate functions, including
inhibition of tumor metastasis and control of reproductive function. In contrast to the plethora
of studies that have analyzed in recent years the regulatory functions of the KiSS-1/GPR54
system, only a limited number of reports have been primarily focused on delineating the
intracellular signaling pathways involved. Nevertheless, there is solid evidence indicating …
