[HTML][HTML] C5aR1 regulates migration of suppressive myeloid cells required for costimulatory blockade-induced murine allograft survival
I Llaudo, M Fribourg, ME Medof, P Conde… - American Journal of …, 2019 - Elsevier
Costimulatory blockade-induced murine cardiac allograft survival requires intragraft
accumulation of CD11b+ Ly6C lo Ly6G− regulatory myeloid cells (Mregs) that expand
regulatory T cells (Tregs) and suppress effector T cells (Teffs). We previously showed that
C5a receptor (C5aR1) signaling on T cells activates Teffs and inhibits Tregs, but whether
and/or how C5aR1 affects Mregs required for transplant survival is unknown. Although
BALB/c hearts survived> 60 days in anti-CD154 (MR1)-treated or cytotoxic T-lymphocyte …
accumulation of CD11b+ Ly6C lo Ly6G− regulatory myeloid cells (Mregs) that expand
regulatory T cells (Tregs) and suppress effector T cells (Teffs). We previously showed that
C5a receptor (C5aR1) signaling on T cells activates Teffs and inhibits Tregs, but whether
and/or how C5aR1 affects Mregs required for transplant survival is unknown. Although
BALB/c hearts survived> 60 days in anti-CD154 (MR1)-treated or cytotoxic T-lymphocyte …