Long-lived, donor-reactive memory B cells (Bmems) can produce alloantibodies that
mediate transplant injury. Autophagy, an intrinsic mechanism of cell organelle/component
recycling, is required for Bmem survival in infectious and model antigen systems, but
whether autophagy affects alloreactive Bmem is unknown. We studied mice with an
inducible yellow fluorescent protein (YFP) reporter expressed under the activation-induced
cytidine deaminase (AID) promoter active in B cells undergoing germinal center reactions …