Erythropoietin receptor-mediated molecular crosstalk promotes T cell immunoregulation and transplant survival

C Purroy, RL Fairchild, T Tanaka… - Journal of the …, 2017 - journals.lww.com
Although spontaneous kidney transplant acceptance/tolerance occurs in mice and
occasionally in humans, mechanisms remain unclear. Herein we test the hypothesis that
EPO, a hormone predominantly produced by the adult kidney, has immunomodulating
properties that are required for spontaneous kidney graft acceptance. In vitro, in a manner
dependent on the EPO receptor and CD131 on antigen-presenting cells, EPO induced the
secretion of active TGFβ by antigen-presenting cells, which in turn converted naïve CD4+ T …