The mucoprotein uromodulin is the most abundant protein in mammalian urine and has
important roles in ion transport, maintenance of water and electrolyte balance, and
clearance of bacteria from the urinary tract. Low urinary uromodulin concentrations have
been associated with increased mortality risk. However, measuring uromodulin in urine has
several preanalytic drawbacks, and sensitive assays for the detection of uromodulin in blood
have become available. In this study, we investigated the association of serum uromodulin …