Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis
M Olden, T Corre, C Hayward, D Toniolo… - Journal of the …, 2014 - journals.lww.com
Uromodulin is expressed exclusively in the thick ascending limb and is the most abundant
protein excreted in normal urine. Variants in UMOD, which encodes uromodulin, are
associated with renal function, and urinary uromodulin levels may be a biomarker for kidney
disease. However, the genetic factors regulating uromodulin excretion are unknown. We
conducted a meta-analysis of urinary uromodulin levels to identify associated common
genetic variants in the general population. We included 10,884 individuals of European …
protein excreted in normal urine. Variants in UMOD, which encodes uromodulin, are
associated with renal function, and urinary uromodulin levels may be a biomarker for kidney
disease. However, the genetic factors regulating uromodulin excretion are unknown. We
conducted a meta-analysis of urinary uromodulin levels to identify associated common
genetic variants in the general population. We included 10,884 individuals of European …