Lipoprotein lipase (LPL) is the rate-limiting enzyme for the hydrolysis of the triglyceride-rich
lipoproteins and plays a critical role in lipoprotein and free fatty acid metabolism. Genetic
manipulation of LPL may be beneficial in the treatment of hypertriglyceridemias, but it is
unknown whether increased LPL activity may be effective in lowering plasma cholesterol
and improving insulin resistance in familial hypercholesterolemic patients. To test the
hypothesis that stimulation of LPL expression may be used as an adjunctive therapy for …