Association of apolipoprotein E in lipoprotein subspecies with risk of dementia

M Koch, ST DeKosky, M Goodman, J Sun… - JAMA Network …, 2020 - jamanetwork.com
Importance The ε4 allele of the apolipoprotein E (APOE) gene and lower apolipoprotein E
(apoE) protein levels in plasma are risk factors for Alzheimer disease, but the underlying
biological mechanisms are not fully understood. Half of plasma apoE circulates on high-
density lipoproteins (HDLs). Higher apoE levels in plasma HDL were previously found to be
associated with lower coronary heart disease risk, but the coexistence of another
apolipoprotein, apoC3, modified this lower risk. Objective To investigate associations …