Apolipoprotein E-containing high-density lipoprotein (HDL) modifies the impact of cholesterol-overloaded HDL on incident coronary heart disease risk: a community …

Y Qi, J Liu, W Wang, M Wang, F Zhao, J Sun… - Journal of Clinical …, 2018 - Elsevier
Background Experimental studies have shown that cholesterol-overloaded high-density
lipoprotein (HDL) can promote the formation of apolipoprotein E (APOE)-containing HDL, a
process correcting the atherogenic function of cholesterol-overloaded HDL. Objective The
objective of the study was to explore whether APOE-containing HDL can attenuate the
defective impact of cholesterol-overloaded HDL on the development of coronary heart
disease (CHD) in humans. Methods We measured APOE-HDL cholesterol (APOE-HDLC) …