[HTML][HTML] Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes

BS Karam, A Chavez-Moreno, W Koh, JG Akar… - Cardiovascular …, 2017 - Springer
BS Karam, A Chavez-Moreno, W Koh, JG Akar, FG Akar
Cardiovascular diabetology, 2017Springer
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several
risk factors promote AF, among which diabetes mellitus has emerged as one of the most
important. The growing recognition that obesity, diabetes and AF are closely intertwined
disorders has spurred major interest in uncovering their mechanistic links. In this article we
provide an update on the growing evidence linking oxidative stress and inflammation to
adverse atrial structural and electrical remodeling that leads to the onset and maintenance …
Abstract
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several risk factors promote AF, among which diabetes mellitus has emerged as one of the most important. The growing recognition that obesity, diabetes and AF are closely intertwined disorders has spurred major interest in uncovering their mechanistic links. In this article we provide an update on the growing evidence linking oxidative stress and inflammation to adverse atrial structural and electrical remodeling that leads to the onset and maintenance of AF in the diabetic heart. We then discuss several therapeutic strategies to improve atrial excitability by targeting pathways that control oxidative stress and inflammation.
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