Quinine enhances photo-inactivation of gram-negative bacteria
The Journal of Infectious Diseases, 2020•academic.oup.com
Background Antimicrobial resistance is a significant concern to public health, and there is a
pressing need to develop novel antimicrobial therapeutic modalities. Methods In this study,
we investigated the capacity for quinine hydrochloride (Q-HCL) to enhance the antimicrobial
effects of antimicrobial blue light ([aBL] 405 nm wavelength) against multidrug-resistant
(MDR) Gram-negative bacteria in vitro and in vivo. Results Our findings demonstrated the
significant improvement in the inactivation of MDR Pseudomonas aeruginosa and …
pressing need to develop novel antimicrobial therapeutic modalities. Methods In this study,
we investigated the capacity for quinine hydrochloride (Q-HCL) to enhance the antimicrobial
effects of antimicrobial blue light ([aBL] 405 nm wavelength) against multidrug-resistant
(MDR) Gram-negative bacteria in vitro and in vivo. Results Our findings demonstrated the
significant improvement in the inactivation of MDR Pseudomonas aeruginosa and …
Background
Antimicrobial resistance is a significant concern to public health, and there is a pressing need to develop novel antimicrobial therapeutic modalities.
Methods
In this study, we investigated the capacity for quinine hydrochloride (Q-HCL) to enhance the antimicrobial effects of antimicrobial blue light ([aBL] 405 nm wavelength) against multidrug-resistant (MDR) Gram-negative bacteria in vitro and in vivo.
Results
Our findings demonstrated the significant improvement in the inactivation of MDR Pseudomonas aeruginosa and Acinetobacter baumannii (planktonic cells and biofilms) when aBL was illuminated during Q-HCL exposure. Furthermore, the addition of Q-HCL significantly potentiated the antimicrobial effects of aBL in a mouse skin abrasion infection model. In addition, combined exposure of aBL and Q-HCL did not result in any significant apoptosis when exposed to uninfected mouse skin.
Conclusions
In conclusion, aBL in combination with Q-HCL may offer a novel approach for the treatment of infections caused by MDR bacteria.
Oxford University Press