Expression of P2X3 and TRPV1 receptors in primary sensory neurons from estrogen receptors-α and estrogen receptor-β knockout mice
T Cho, VV Chaban - Neuroreport, 2012 - journals.lww.com
In women, pain symptoms and nociceptive thresholds vary with the reproductive cycle,
suggesting the role of estrogen receptors (ERs) in modulating nociception. Our previous
data strongly suggest an interaction between ERs and ATP-induced purinergic (P2X3) as
well as ERs and capsaicin-induced vanilloid (TRPV1) receptors at the level of dorsal root
ganglion (DRG) neurons. In this study, we investigated the expression of P2X3 and TRPV1
receptors by western blotting and immunohistochemistry in lumbosacral DRGs from wild …
suggesting the role of estrogen receptors (ERs) in modulating nociception. Our previous
data strongly suggest an interaction between ERs and ATP-induced purinergic (P2X3) as
well as ERs and capsaicin-induced vanilloid (TRPV1) receptors at the level of dorsal root
ganglion (DRG) neurons. In this study, we investigated the expression of P2X3 and TRPV1
receptors by western blotting and immunohistochemistry in lumbosacral DRGs from wild …