Estrogen metabolism and breast cancer
H Samavat, MS Kurzer - Cancer letters, 2015 - Elsevier
H Samavat, MS Kurzer
Cancer letters, 2015•ElsevierThere is currently accumulating evidence that endogenous estrogens play a critical role in
the development of breast cancer. Estrogens and their metabolites have been studied in
both pre-and postmenopausal women with more consistent results shown in the latter
population, in part because of large hormonal variations during the menstrual cycle and far
fewer studies having been performed in premenopausal women. In this review we describe
in detail estrogen metabolism and associated genetic variations, and provide a critical …
the development of breast cancer. Estrogens and their metabolites have been studied in
both pre-and postmenopausal women with more consistent results shown in the latter
population, in part because of large hormonal variations during the menstrual cycle and far
fewer studies having been performed in premenopausal women. In this review we describe
in detail estrogen metabolism and associated genetic variations, and provide a critical …
Abstract
There is currently accumulating evidence that endogenous estrogens play a critical role in the development of breast cancer. Estrogens and their metabolites have been studied in both pre- and postmenopausal women with more consistent results shown in the latter population, in part because of large hormonal variations during the menstrual cycle and far fewer studies having been performed in premenopausal women. In this review we describe in detail estrogen metabolism and associated genetic variations, and provide a critical review of the current literature regarding the role of estrogens and their metabolites in breast cancer risk.
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