Estradiol and testosterone differently affect visceral pain-related behavioural responses in male and female rats
AM Aloisi, G Affaitati, I Ceccarelli, P Fiorenzani… - European journal of …, 2010 - Elsevier
In the study of pain, the presence of sex differences is well known, with female subjects
being more affected in a number of chronic painful conditions; however, the underlying
mechanisms and the involvement of gonadal hormones, are still controversial. This study
evaluated visceral pain in a validated rat model of artificial calculosis and the effects of
estradiol and testosterone administration. Adult male and female rats were divided into
groups and treated with one of the substances or Oil (vehicle) for 5 days, starting 2 days …
being more affected in a number of chronic painful conditions; however, the underlying
mechanisms and the involvement of gonadal hormones, are still controversial. This study
evaluated visceral pain in a validated rat model of artificial calculosis and the effects of
estradiol and testosterone administration. Adult male and female rats were divided into
groups and treated with one of the substances or Oil (vehicle) for 5 days, starting 2 days …