[HTML][HTML] Pharmacokinetics and effects of 17β-estradiol and progesterone implants in ovariectomized rats
CA Mannino, SM South, CE Inturrisi… - The Journal of …, 2005 - Elsevier
For the pharmacokinetic evaluation of Silastic capsules, ovariectomized (OVX) rats were
implanted subcutaneously with this dosage form containing 17β-estradiol (5, 10, 15, or 20%
in cholesterol, where 5% 17β-estradiol equals 0.4 mg) or progesterone (20, 40, 110, or 220
mg of crystalline progesterone). The time-course of serum 17β-estradiol and progesterone
released from these capsules in the OVX rat is characterized by an initial increase in serum
hormone levels followed by a decline and then an apparent steady-state that persists from 7 …
implanted subcutaneously with this dosage form containing 17β-estradiol (5, 10, 15, or 20%
in cholesterol, where 5% 17β-estradiol equals 0.4 mg) or progesterone (20, 40, 110, or 220
mg of crystalline progesterone). The time-course of serum 17β-estradiol and progesterone
released from these capsules in the OVX rat is characterized by an initial increase in serum
hormone levels followed by a decline and then an apparent steady-state that persists from 7 …