Assessment of spontaneous alternation, novel object recognition and limb clasping in transgenic mouse models of amyloid-β and tau neuropathology
CJ Miedel, JM Patton, AN Miedel, ES Miedel… - JoVE (Journal of …, 2017 - jove.com
Here we describe a staged, behavioral testing approach that can be used to screen for
compounds that exhibit in vivo efficacy on cognitive and functional motor behaviors in
transgenic mouse models of β-amyloidosis and tauopathy. The paradigm includes tests for
spontaneous alternation in a Y-maze, novel object recognition, and limb clasping. These
tests were selected because they: 1) interrogate function of cognitive or motor domains and
the correlate neural circuitry relevant to the human disease state, 2) have clearly defined …
compounds that exhibit in vivo efficacy on cognitive and functional motor behaviors in
transgenic mouse models of β-amyloidosis and tauopathy. The paradigm includes tests for
spontaneous alternation in a Y-maze, novel object recognition, and limb clasping. These
tests were selected because they: 1) interrogate function of cognitive or motor domains and
the correlate neural circuitry relevant to the human disease state, 2) have clearly defined …