Synthesis and deposition of extracellular matrix (ECM) within the glomerulus and interstitium
characterizes renal fibrosis, but the mechanisms underlying this process are incompletely
understood. The profibrotic cytokine TGF-β1 modulates the expression of certain microRNAs
(miRNAs), suggesting that miRNAs may have a role in the pathogenesis of renal fibrosis.
Here, we exposed proximal tubular cells, primary mesangial cells, and podocytes to TGF-β1
to examine its effect on miRNAs and subsequent collagen synthesis. TGF-β1 reduced …