Connective tissue proliferation and growth factors in animal models of Duchenne muscular dystrophy

S Iannaccone, A Quattrini, S Smirne, M Sessa… - Journal of the …, 1995 - Elsevier
The difference in the lifespan of dy and mdx mice could be due to different muscle
regeneration capabilities. In mdx an involvement of bFGF in stimulating regeneration has
been postulated. The aim of our work was to detect the presence, and to study the
distribution, of muscular and connective tissue growth factors in mdx and dy mice at different
stages of muscle pathology. From 7 to 10 weeks of age the difference between the two
dystrophic mice becomes evident. At 13 weeks the dy mouse presents a predominance of …