Intermediate filament expression in astrocytic neoplasms
M Cosgrove, PL Fitzgibbons, A Sherrod… - The American journal …, 1989 - journals.lww.com
Immunohistochemical analysis of 30 paraffin-embedded astrocytic neoplasms was
performed to correlate the expression of intermediate filament proteins with histologic
subtype. Each tumor was studied with monoclonal antibodies to keratin, vimentin, desmin,
200-kd neurofilament protein, and glial fibrillary acidic protein (GFAP). Immunoreactivity with
the anti-keratin monoclonal antibodies AE1 and AE3 was demonstrated in 24 cases (80%)
including 4 of 6 (66%) well-differentiated astrocytomas (WDAs), 10 of 12 (83%) anaplastic …
performed to correlate the expression of intermediate filament proteins with histologic
subtype. Each tumor was studied with monoclonal antibodies to keratin, vimentin, desmin,
200-kd neurofilament protein, and glial fibrillary acidic protein (GFAP). Immunoreactivity with
the anti-keratin monoclonal antibodies AE1 and AE3 was demonstrated in 24 cases (80%)
including 4 of 6 (66%) well-differentiated astrocytomas (WDAs), 10 of 12 (83%) anaplastic …
