Expression mapping using a retroviral vector for CD8+ T cell epitopes: definition of a Mycobacterium tuberculosis peptide presented by H2-Dd
T Aoshi, M Suzuki, M Uchijima, T Nagata… - Journal of immunological …, 2005 - Elsevier
Identification of CD8+ T cell epitopes is important because detection of specific CD8+ T cells
after infection or immunization requires prior knowledge of epitope specificity. Furthermore,
identification of CD8+ T cell epitopes permits the development of specific preventive and
therapeutic approaches to both infections and tumors. Thus far, CD8+ T cell epitopes have
been identified either using an overlapping peptide library covering an entire protein, or
using algorithms designed to identify likely peptides that bind to major histocompatibility …
after infection or immunization requires prior knowledge of epitope specificity. Furthermore,
identification of CD8+ T cell epitopes permits the development of specific preventive and
therapeutic approaches to both infections and tumors. Thus far, CD8+ T cell epitopes have
been identified either using an overlapping peptide library covering an entire protein, or
using algorithms designed to identify likely peptides that bind to major histocompatibility …