[HTML][HTML] Prognostic value of MICA/B in cancers: a systematic review and meta-analysis

Y Zhao, N Chen, Y Yu, L Zhou, C Niu, Y Liu, H Tian… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Y Zhao, N Chen, Y Yu, L Zhou, C Niu, Y Liu, H Tian, Z Lv, F Han, J Cui
Oncotarget, 2017ncbi.nlm.nih.gov
Purpose MHC class I chain related-proteins A (MICA) and B (MICB) are natural killer group
2D ligands that mediate tumor surveillance. Several studies have suggested that MICA/B
levels predict clinical outcomes in patients with cancer; however, this remains contentious.
Here, we present a systematic review and meta-analysis of available studies of the
prognostic value of MICA/B in cancer. Materials and Methods We searched PubMed,
Embase, Clinicaltrials. gov, and Cochrane Library to identify studies published from …
Abstract
Purpose
MHC class I chain related-proteins A (MICA) and B (MICB) are natural killer group 2D ligands that mediate tumor surveillance. Several studies have suggested that MICA/B levels predict clinical outcomes in patients with cancer; however, this remains contentious. Here, we present a systematic review and meta-analysis of available studies of the prognostic value of MICA/B in cancer.
Materials and Methods
We searched PubMed, Embase, Clinicaltrials. gov, and Cochrane Library to identify studies published from inception to July 2017 that assessed MICA/B in patients with cancer. The hazard ratio (HR) and 95% confidence interval (CI) of MICA/B were extracted for overall survival (OS) analysis.
Results
A total of 19 studies comprising 2,588 patients with 10 different types of cancer were included in the study. Low sMICA/B levels were found associated with significantly longer OS (HR= 1.65, 95% CI [1.42–1.92], P< 0.00001). Patients with cancers of digestive system that exhibited high MICA/B expression had significantly longer OS in (HR= 0.56, 95% CI [0.39–0.80], P= 0.002) compared with those with lower MICA/B expression (I 2= 35%, P= 0.18).
Conclusions
Serum soluble MICA/B represents a potential prognostic marker in various human cancers. High cell-surface MICA/B expression in cancers of the digestive system was found associated with increased survival.
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