Activation of extracellular signal-regulated kinase 1/2 and Sp1 may contribute to the expression of tissue inhibitor of metalloproteinases-1 induced by transforming …
W Tang, J Yang, F Zhang, H Guo, F Peng, X Wang - Cytotherapy, 2014 - Elsevier
Background aims Tissue inhibitor of metalloproteinases-1 (TIMP-1) plays an important role
in the development of pulmonary arterial hypertension. However, the molecular regulatory
mechanisms of TIMP-1 in the pulmonary arteries are not fully understood, especially in
human pulmonary arterial smooth muscle cells (HPASMCs). We investigated the signaling
pathway involved in the regulation of TIMP-1 in HPASMCs induced by transforming growth
factor (TGF)-β1. Methods Cultured HPASMCs were incubated with different concentrations …
in the development of pulmonary arterial hypertension. However, the molecular regulatory
mechanisms of TIMP-1 in the pulmonary arteries are not fully understood, especially in
human pulmonary arterial smooth muscle cells (HPASMCs). We investigated the signaling
pathway involved in the regulation of TIMP-1 in HPASMCs induced by transforming growth
factor (TGF)-β1. Methods Cultured HPASMCs were incubated with different concentrations …