1α, 25-dihydroxyvitamin D3 encapsulated in nanoparticles prevents venous neointimal hyperplasia and stenosis in porcine arteriovenous fistulas
Background Few therapies prevent venous neointimal hyperplasia (VNH) and venous
stenosis (VS) formation in arteriovenous fistulas (AVF). Expression of the immediate early
response gene X-1 (Iex-1), also known as Ier3, is associated with VNH and stenosis in
murine AVFs. The study aimed to determine if local release of Ier3 long-acting inhibitor 1α,
25 (OH) 2 D 3 from poly (lactic-co-glycolic acid)(PLGA) nanoparticles embedded in a
thermosensitive Pluronic F127 hydrogel (1, 25 NP) could affect VNH/VS formation in a large …
stenosis (VS) formation in arteriovenous fistulas (AVF). Expression of the immediate early
response gene X-1 (Iex-1), also known as Ier3, is associated with VNH and stenosis in
murine AVFs. The study aimed to determine if local release of Ier3 long-acting inhibitor 1α,
25 (OH) 2 D 3 from poly (lactic-co-glycolic acid)(PLGA) nanoparticles embedded in a
thermosensitive Pluronic F127 hydrogel (1, 25 NP) could affect VNH/VS formation in a large …