Memory T cells need CD28 costimulation to remember
AC Boesteanu, PD Katsikis - Seminars in immunology, 2009 - Elsevier
AC Boesteanu, PD Katsikis
Seminars in immunology, 2009•ElsevierThe activation and expansion of naïve T cells require costimulatory signals provided by
CD28 and TNF family members. In contrast, for many years it was believed that memory T
cells do not require CD28 costimulation for expansion during secondary responses. This
was based on in vitro experiments that suggested the re-activation of memory T cells is
somewhat independent of costimulation. Recent in vivo evidence, however, has challenged
this and shown that both CD4+ and CD8+ memory T cells require CD28 costimulation for …
CD28 and TNF family members. In contrast, for many years it was believed that memory T
cells do not require CD28 costimulation for expansion during secondary responses. This
was based on in vitro experiments that suggested the re-activation of memory T cells is
somewhat independent of costimulation. Recent in vivo evidence, however, has challenged
this and shown that both CD4+ and CD8+ memory T cells require CD28 costimulation for …
The activation and expansion of naïve T cells require costimulatory signals provided by CD28 and TNF family members. In contrast, for many years it was believed that memory T cells do not require CD28 costimulation for expansion during secondary responses. This was based on in vitro experiments that suggested the re-activation of memory T cells is somewhat independent of costimulation. Recent in vivo evidence, however, has challenged this and shown that both CD4+ and CD8+ memory T cells require CD28 costimulation for maximal expansion and pathogen clearance. This requirement has important implications for host immunity, vaccine development and immunotherapeutics.
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