[HTML][HTML] Pathogen Stimulation History Impacts Donor-Specific CD8+ T Cell Susceptibility to Costimulation/Integrin Blockade Based Therapy
IR Badell, WH Kitchens, ME Wagener… - American Journal of …, 2015 - Elsevier
Recent studies have shown that the quantity of donor-reactive memory T cells is an
important factor in determining the relative heterologous immunity barrier posed during
transplantation. Here, we hypothesized that the quality of T cell memory also potently
influences the response to costimulation blockade-based immunosuppression. Using a
murine skin graft model of CD8+ memory T cell–mediated costimulation blockade
resistance, we elicited donor-reactive memory T cells using three distinct types of pathogen …
important factor in determining the relative heterologous immunity barrier posed during
transplantation. Here, we hypothesized that the quality of T cell memory also potently
influences the response to costimulation blockade-based immunosuppression. Using a
murine skin graft model of CD8+ memory T cell–mediated costimulation blockade
resistance, we elicited donor-reactive memory T cells using three distinct types of pathogen …