[HTML][HTML] Inhibition of cardiomyocyte hypertrophy by protein arginine methyltransferase 5
M Chen, B Yi, J Sun - Journal of Biological Chemistry, 2014 - ASBMB
Protein arginine methyltransferase 5 (PRMT5), a protein arginine methyltransferase that
catalyzes the symmetrical dimethylation of arginine residues within target proteins, has been
implicated in many essential cellular processes ranging from the regulation of gene
expression to cell proliferation and differentiation. PRMT5 is highly expressed in the heart;
the functional role of PRMT5 in the heart, however, remains largely elusive. In the present
study, we show that PRMT5 specifically interacts with GATA4 in both co-transfected …
catalyzes the symmetrical dimethylation of arginine residues within target proteins, has been
implicated in many essential cellular processes ranging from the regulation of gene
expression to cell proliferation and differentiation. PRMT5 is highly expressed in the heart;
the functional role of PRMT5 in the heart, however, remains largely elusive. In the present
study, we show that PRMT5 specifically interacts with GATA4 in both co-transfected …