[HTML][HTML] Protein arginine methyltransferase 5 (PRMT5) signaling suppresses protein kinase Cδ-and p38δ-dependent signaling and keratinocyte differentiation
SR Kanade, RL Eckert - Journal of Biological Chemistry, 2012 - ASBMB
PKCδ is a key regulator of keratinocyte differentiation that activates p38δ phosphorylation
leading to increased differentiation as measured by an increased expression of the
structural protein involucrin. Our previous studies suggest that p38δ exists in association
with protein partners. A major goal is to identify these partners and understand their role in
regulating keratinocyte differentiation. In this study we use affinity purification and mass
spectrometry to identify protein arginine methyltransferase 5 (PRMT5) as part of the p38δ …
leading to increased differentiation as measured by an increased expression of the
structural protein involucrin. Our previous studies suggest that p38δ exists in association
with protein partners. A major goal is to identify these partners and understand their role in
regulating keratinocyte differentiation. In this study we use affinity purification and mass
spectrometry to identify protein arginine methyltransferase 5 (PRMT5) as part of the p38δ …