EPZ015666, a selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an antitumour effect in retinoblastoma
X Liu, JZ He, L Mao, Y Zhang, WW Cui, S Duan… - Experimental Eye …, 2021 - Elsevier
Retinoblastoma (RB) is the most common intraocular malignant tumour in infants, and
chemotherapy has been the primary therapy method in recent years. PRMT5 is an important
member of the protein arginine methyltransferase family, which plays an important role in
various tumours. Our study showed that PRMT5 was overexpressed in retinoblastoma and
played an important role in retinoblastoma cell growth. EPZ015666 is a novel PRMT5
inhibitor, and we found that it inhibited retinoblastoma cell proliferation and led to cell cycle …
chemotherapy has been the primary therapy method in recent years. PRMT5 is an important
member of the protein arginine methyltransferase family, which plays an important role in
various tumours. Our study showed that PRMT5 was overexpressed in retinoblastoma and
played an important role in retinoblastoma cell growth. EPZ015666 is a novel PRMT5
inhibitor, and we found that it inhibited retinoblastoma cell proliferation and led to cell cycle …