Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line.
M Wabl, PD Burrows, A Von Gabain… - Proceedings of the …, 1985 - pnas.org
M Wabl, PD Burrows, A Von Gabain, C Steinberg
Proceedings of the National Academy of Sciences, 1985•pnas.orgMost cells in the well-known pre-B-lymphocyte line 18-81 have correctly assembled genes
for both alleles at the immunoglobulin heavy chain locus. Only one allele is" active"; the
other," silent" allele contains an amber termination codon. The rate of reversion of this amber
codon was determined to be 0.3-1 X 10 (-4) per cell generation. This high rate is termed
hypermutation.
for both alleles at the immunoglobulin heavy chain locus. Only one allele is" active"; the
other," silent" allele contains an amber termination codon. The rate of reversion of this amber
codon was determined to be 0.3-1 X 10 (-4) per cell generation. This high rate is termed
hypermutation.
Most cells in the well-known pre-B-lymphocyte line 18-81 have correctly assembled genes for both alleles at the immunoglobulin heavy chain locus. Only one allele is "active"; the other, "silent" allele contains an amber termination codon. The rate of reversion of this amber codon was determined to be 0.3-1 X 10(-4) per cell generation. This high rate is termed hypermutation.
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