[HTML][HTML] Diversity of polyubiquitin chains
A Adhikari, ZJ Chen - Developmental cell, 2009 - cell.com
A Adhikari, ZJ Chen
Developmental cell, 2009•cell.comPolyubiquitin chains linked through different lysines of ubiquitin may exert both proteasome-
dependent and-independent functions. In a recent Cell issue, Xu et al. employ quantitative
proteomics to profile polyubiquitin linkages in yeast. They find that linkages through all
lysines of ubiquitin, except lysine-63, can target proteasomal degradation in vivo, and that
lysine-11 polyubiquitination is important for endoplasmic reticulum-associated degradation
(ERAD).
dependent and-independent functions. In a recent Cell issue, Xu et al. employ quantitative
proteomics to profile polyubiquitin linkages in yeast. They find that linkages through all
lysines of ubiquitin, except lysine-63, can target proteasomal degradation in vivo, and that
lysine-11 polyubiquitination is important for endoplasmic reticulum-associated degradation
(ERAD).
Polyubiquitin chains linked through different lysines of ubiquitin may exert both proteasome-dependent and -independent functions. In a recent Cell issue, Xu et al. employ quantitative proteomics to profile polyubiquitin linkages in yeast. They find that linkages through all lysines of ubiquitin, except lysine-63, can target proteasomal degradation in vivo, and that lysine-11 polyubiquitination is important for endoplasmic reticulum-associated degradation (ERAD).
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